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KMID : 0369820070370050275
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Jorunal of Korean Pharmaceutical Sciences
2007 Volume.37 No. 5 p.275 ~ p.280
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Disintegrating Behavior of A Rapidly Disintegrating Famotidine Tablet Formulation
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Park Jeong-Sook
Shin Kwang-Hyun
Park Jong-Bum
Lee Si-Beum
Hwang Sung-Joo
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Abstract
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A rapidly disintegration famotidine tablet formulation in the oral cavity was developed using microcrystalline cellulose (MCC) and low-substituted hydroxypropyl cellulose (L-HPC), or additionally cropovidone as an internal disintegrant. Effects of disintegrants on the disintegration time in vitro and hardness were evaluated. Average wetting time of the tablets prepared in scale-up manufacturing process was less than 15 sec. Among the formulations tested, the tablet prepared with crospovidone as an internal disintegrant and Emcocel as an external disintegrant showed fastest disintegration. These results may suggest that crospovidone and Emcocel possessed excellent wetting nature, which result in the rapid disintegration of tablet.
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KEYWORD
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Rapidly disintegrating tablets, Crospovidone, Emcocel, Famotidine
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